Opisthorchis viverrini and clonorchis sinensis biological. Opisthorchis viverrini ov infection is the main risk factor for cholangiocarcinoma and is often found in northeastern thailand. Research highlights opisthorchis viverrini, fishborne parasite infection liver fluke. Infection with the parasite is called opisthorchiasis. Opisthorchis viverrini infection, which brings to chronic inflammation. In thailand and neighbouring countries, human opisthorchiasis is caused by o. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus.
Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a member of the family opisthorchiidae. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma. Opisthorchiasis is a parasitic disease that can infect fish eating mammals, including humans. In 2005, the total number of individuals infected with opisthorchis spp. The eggs of opisthorchis viverrini are ingested by snails in fresh water. Opisthorchis viverrini is found mainly in northeast thailand, laos, cambodia, and central and southern vietnam.
The major risk factor for cca in thailand is the carcinogenic liver fluke opisthorchis viverrini ov infection. Cholangiocarcinoma, like opisthorchiasis, is highly prevalent in isan region of. Detection and discrimination of liver fluke in surin people. Synonymes distoma viverrini poirier, 1886 protonyme prevalence du cholangiocarcinome et do. Opisthorchis infection is a known cause of cholangiocarcinoma, bile duct cancer. Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. The results reveal that 510 participants were 242 males and 268 females. Moreover, other mechanisms that enhance cca development are also postulated. Opisthorchis viverrini is a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma chca. Opisthorchis viverrini, adult worm image from ash, 1997.
Worms and human disease 2nd edition ralph muller, dsc, phd, fibiol department of infectious and tropical diseases london school of hygiene and tropical medicine university of london, uk and former director international institute of parasitology st albans, hertfordshire, uk with contributions and the chapter on immunology of helminths from. After the eggs hatch, infected snails will release microscopic larvae that can enter freshwater fish. People become infected when eating raw or undercooked fish that contains the parasite. Opisthorchis viverrini description, causes and risk factors. Morphological study on cercarial of opisthorchis viverrini.
Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. Pdf opisthorchis viverrini and opisthorchis felineus. The three major liver trematodes flukes that infect humans are clonorchis sinensis, opisthorchis species, and fasciola hepatica. Liver fluke infection casued by opisthorchis viverrini is a major public health problem. Dicrocoelium dendriticum, the lancet liver fluke, is a parasite fluke that tends to live in cattle or other grazing mammals. Pdf epidemiology of opisthorchis viverrini paiboon. Gymnocephalous 72%, parapleurolophocercous 22% pleurolophocercous 6%. Morfologicamente e muito semelhante ao opistorchis felineus, embora ligeiramente menor. Opisthorchis viverrini wikipedia, a enciclopedia livre. Clonorchis sinensis, opisthorchis viverrini and opisthorchis felineus are three closely related species that produce similar clinical manifestations in humans. O viverrini is highly prevalent in thailand and laos while c. Opisthorchis viverrini medigoo health medical tests and.
Opisthorchis viverrini and clonorchis sinensis were considered by a previous iarc working group in 1994. The prevalence of ov infection and the incidence of. Ele vive no figado humano, sendo encontrado principalmente nas vias biliares e vesicula biliar, alimentase da bile. This study is a crosssectionalanalytic study, aimed to determine actual levels of o. Cholangiocarcinoma cca is still a major public health problem in thailand. Morbidity assessment of opisthorchis viverrini infection in. Opisthorchis viverrini an overview sciencedirect topics. The adult flukes deposit fully developed eggs that are passed in the feces. They have a knob at the abopercular end that may be prominent, inconspicuous, or absent. May 16, 2016 the oriental liver flukes opisthorchis viverrini, opisthorchis felineus, chlonorchis sinensis are important causes of human disease. In 198081, the prevalence in the north, northeastern, centre.
Morbidity assessment of opisthorchis viverrini infection. Opisthorchis viverrini and clonorchis sinensis a opisthorchis viverrini thailand is the most endemic country for opisthorchiasis due to o. Since that time, new data have become available, these have been incorporated in the monograph, and taken into consideration in the present evaluation. Pdf opisthorchis viverrini and opisthorchiasis banchob. A crosssection study was conducted using several secondary data including mortality and incidence of. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Characterization of tubulin from liver fluke, opisthorchis. In southeast asia, opisthorchiasis alone was responsible for 63,000 of years of life lost and 74,000 disabilityadjusted life years dalys.
The ecology of the bithynia first intermediate hosts of. Advanced periductal fibrosis from infection with the. The oriental liver flukes opisthorchis viverrini, opisthorchis felineus, chlonorchis sinensis are important causes of human disease. After ingestion, the liver flukes grow to adult worms that live inside the human. People are infected after eating raw or undercooked fish. Although infections are identified throughout southeast asia, the epicenter is northeast thailand, where high prevalence coexists with a high. Son cycle fait intervenir deux hotes intermediaires en eau douce. Worms and human disease shahid sadoughi university of. The majorities of information resources regarding prevention and control of. Characterization of tubulin from liver fluke, opisthorchis viverrini. Opisthorchis viverrini bithynia siamensis goniomphalos. These pathogen safety data sheets, regulated under workplace hazardous materials information system whmis legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious microorganisms. Much of what is presently known about dicrocoelium dendriticum is the result of the work of the naturalist wendell krull.
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